Inscopix declined to provide a price for the system, explaining that the cost varies regionally.ĬN Bio released the PhysioMimix™ OOC Multi-Organ Microphysiological System in March 2021 after about 10 years of research and development through a collaboration between the Defense Advanced Research Projects Agency (DARPA) and MIT. Stamatakis says that Inscopix is now working to layer electrophysiology recordings and enhanced behavioral analyses into the miniscope.
This allows for analysis of the relationship between neuronal activity and vascular dynamics, including capillary diameter and red blood cell velocity, in the brain. In addition to tracking two neuronal populations, researchers can use the miniscope to juxtapose fluorescence signals from calcium influx in neurons and plasma in blood. “It’s been a breakthrough for circuit neuroscience,” Tan, who highlighted the dual miniscope’s merit in a video and webinar for Inscopix, tells The Scientist. Kelly Tan, a neurologist at the University of Basel, Switzerland, uses the nVue system to study communication between neuronal populations in a mouse model of Parkinson’s disease.
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“ is going to give neuroscientists an unprecedented view into how these different brain signals communicate and talk with each other during naturalistic behaviors.” The system’s built-in data acquisition and processing software helps complete the picture.īeyond basic biology, the dual miniscope can aid translational research for neuropsychiatric and neurodegenerative conditions, such as anxiety or Alzheimer’s disease. Two-photon microscopy also allows simultaneous imaging of two neuronal populations, but it is mostly limited to the brain cortex and requires animals to be constrained by the head, compromising the study of behavior, she says. The miniscope offers another advantage, Stamatakis adds: longitudinal deep-brain imaging, wherein the same cells can be analyzed over multiple imaging sessions. Thus far, researchers have mounted nVue on the heads of rodents, birds, and monkeys. This “miniaturized microscope” relies on red and green fluorescent indicators targeted to neurons to trace calcium ion influx and, in turn, the activity of two different neuronal populations in freely moving animals, according to Alice Stamatakis, director of applications at Inscopix, the company that makes the nVue. Weighing in at two grams, the nVue TM System is about the size of a Lego brick. It suggests that the global biomedical apparatus is robust enough to address a pressing and pointed concern while not losing ground in fields not directly related to that crisis. In a way, it’s heartening that scientific advances have continued to occur in spaces outside of the crucial coronavirus focus. Since the last installment of our Top 10 innovations, the world has witnessed the successful deployment of multiple COVID-19 vaccines, and those are, in their own right, truly awe-inspiring innovations. The winners of this year’s competition include an implantable miniscope that can track activity in the brains of freely moving organisms a microfluidic device that aims to recapitulate whole-organism physiology and a few products that build on the emerging trend toward characterizing individual cells, with the added components of spatial information or multi-omics. The list of this year’s Top 10 Innovations winners reflects these shared goals with a couple of products that can help researchers better understand the biological realities of SARS-CoV-2 infections, interrogating cells neighboring those infected with the virus, for example, and the immune system’s reaction to it over time.īut 2021’s innovation landscape also includes laboratory and clinical products that provide a more expansive view on biology.
With the COVID-19 pandemic dragging toward a most unwelcome third year, it’s not surprising that the biomedical community has continued to focus on diagnosing and treating the disease.
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